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CYP2E1 enzymes work in the mitochondria and endoplasmic reticulum in response to high ethanol levels, and this produces a lot of ROS and oxidative stress.[ref][ref] Related article : CYP2E1 gene variants | Alcohol use disorder Calcium signaling and mitochondria: In addition to their vital role in cellular energy production, mitochondria also participate in signaling between cells using calcium ions
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Vanderlelie and Perkins [7] evaluated the oxidative stress at the end of the reproduction in rats in placental and liver tissues, but they do not describe the alteration of GP activity, resulting from the coordination of tissue GSH reductase and GSSG peroxidase enzyme activities in both selenium deficiency and L-NAME oral administration
